Pfizer/BioNTech says three doses 'effective' against Omicron

Prepared doses of Pfizer Covid-19 booster vaccines are pictured at a temporary vaccination centre set up inside St John's Church in west London on December 4, 2021. (Photo: AFP)
FRANKFURT— Two doses of the BioNTech and Pfizer coronavirus vaccine may not be enough to protect against the Omicron strain, the companies warned Wednesday, but they stressed it was "still effective" after a third jab.اضافة اعلان

The companies' news was called reassuring by experts, and came as the first independent data from labs around the world emerged, suggesting that the new variant is better at evading vaccine-trained immunity than those before it.

In preliminary results published on Wednesday, Pfizer and BioNTech said their vaccine "is still effective in preventing COVID-19, also against Omicron, if it has been administered three times".

But they warned that "the Omicron variant is probably not sufficiently neutralized after two doses".

According to early laboratory research using blood serum from vaccinated people, a booster third dose generated around the same level of antibodies against Omicron as is seen after a second dose with the initial strain.
Their results have not been peer reviewed.

"We still need to be very measured and take a wait and see approach, but I think what we do have is at least encouraging," Virologist Angela Rasmussen of Canada's Vaccine and Infectious Disease Organization told AFP. 
"Boosters will definitely be helpful in keeping the rate of Omicron breakthrough slower," she added.

Boosters urged

WHO chief Tedros Adhanom Ghebreyesus on Wednesday summarized what is so far known about Omicron — it poses higher infection risks to people who have already had the virus or been vaccinated than previous variants, and there is a preliminary indication it could cause milder disease.

But even if confirmed to be less severe, the variant is likely even more transmissible than Delta, meaning it could reach and thus sicken more people.
Speaking at a press conference, BioNTech CEO Ugur Sahin said that reducing the time required between second and third doses of the vaccine was the "right way to go" to increase protection through the winter.

The UK has begun giving booster shots to individuals at least three months after their second dose, while the delay to receive an additional shot is longer elsewhere.

The vaccine-makers said that an Omicron-specific version of the jab, currently in development by BioNTech, would be ready for delivery by March, pending regulatory approval.

The decision to switch production to the tailored vaccine would depend on Omicron's spread.

The detection of the first Omicron cases two weeks ago coincided with soaring infection numbers across the world, and the variant added fuel to concerns about a global COVID resurgence.

Dozens of nations have re-imposed border restrictions in response to the spread of the new virus variant and raised the possibility of a return of economically punishing lockdowns.

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