Vitamin B12 is an essential nutrient, playing a vital role in the formation of red blood cells, nerve function, and DNA production. Deficiency is well-known to cause fatigue, numbness, and memory problems.
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What often goes unnoticed, however, is that an excess of Vitamin B12—especially from supplements or injections—may also trigger health issues. While excessive intake from food and beverages is generally safe (as the vitamin is water-soluble and excreted in urine), high doses from supplements can occasionally cause rare but serious side effects.
Here are seven unusual symptoms that may signal excessive Vitamin B12 levels:
Acne and Skin Rash
One of the most visible side effects of excessive Vitamin B12 is acne, especially on the face and upper back. Research shows that high doses of B12 can alter skin bacteria (such as Propionibacterium acnes), triggering inflammation and breakouts. If acne, particularly cystic or inflammatory, worsens after starting a B12 supplement, overconsumption may be the cause.
Pain and Numbness in Hands and Feet
Though tingling is usually linked to deficiency, excess B12 may also impair nerve activity. Rarely, high doses can cause peripheral neuropathy, presenting as burning, tingling, or numbness in the extremities. Medical advice is essential if such symptoms occur after injections or supplements.
Facial Flushing
Sudden redness of the face, sometimes with warmth or itching, can follow high oral doses or injections of Vitamin B12. This reaction may be due to blood vessel dilation caused by histamine release or increased blood volume. While temporary, recurring episodes should not be ignored.
Digestive Issues
Some individuals may experience nausea, vomiting, mild diarrhea, or abdominal cramps after high-dose B12 intake. Although such symptoms can have many causes, their onset following supplementation suggests a possible connection. People with sensitive stomachs should monitor this closely.
Anxiety or Insomnia
While B12 is essential for brain health, excessive amounts can overstimulate the nervous system. Reports link high doses to anxiety, restlessness, or even panic attacks—possibly due to altered neurotransmitter levels, especially when combined with other B vitamins like B6. Persistent insomnia or tension warrants a review of supplement use.
High Blood Pressure
Some studies and case reports suggest a temporary spike in blood pressure following large B12 injections. This may result from increased blood flow or sympathetic nervous system activation. Individuals with hypertension or cardiovascular disease should monitor blood pressure closely while on high doses.
Should You Worry About Elevated Vitamin B12 Levels?
The recommended daily allowance (RDA) for Vitamin B12 is 2.4 micrograms. By comparison, most over-the-counter supplements provide 500–5000 micrograms—far above the body’s daily needs.
Although the body can excrete excess amounts, consistently high doses may worsen the symptoms listed above. Anyone experiencing unusual effects while taking B12—whether via injection or supplements—should consult a doctor. A blood test may be advised to assess B12 levels and adjust dosage accordingly.
Source: Healthsite
