A well-known spice is drawing the attention of experts after recent studies revealed its potential role as a natural antidepressant. Saffron—renowned for its vibrant color and distinctive flavor in dishes such as paella and herbal drinks—is emerging as a promising option for improving mood and reducing symptoms of depression. Psychiatrist Dr. Daniel Amen expressed his enthusiasm in an interview with Fox News about incorporating saffron as a supportive tool for mental health.
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7 Health Benefits of Saffron… But Beware of Misuse
“I love saffron very much… I’m Lebanese, and people of the Middle East cook with a lot of saffron,” he said. “There’s even a common saying in Iran: If you’re very happy, you must have eaten saffron.” Dr. Amen noted research showing that around 30 milligrams of saffron was “just as effective” as antidepressants in randomized trials.
While most selective serotonin reuptake inhibitors (SSRIs) help improve mood, they also carry the risk of reducing sexual function. Saffron, however, appears to have the opposite effect, according to Amen.
“Saffron increased sexual function (according to the research),” he added. Various studies have also shown that saffron supports memory and concentration.
A recent study published in Reviews in Clinical Medicine (2025) linked saffron to a reduction in premenstrual syndrome (PMS) symptoms. After eight to twelve weeks of using saffron, participants reported that the supplement “significantly reduced” the severity of PMS.
Additional research published by Cambridge University Press in May 2025 highlighted saffron’s ability to alleviate symptoms of depression.
The review analyzed 192 trials involving more than 17,000 patients and 44 different types of dietary supplements to determine which were effective against depression. Saffron was identified as the most effective, demonstrating a moderate to strong antidepressant effect.
The meta-analysis also examined how these nutraceuticals interacted with prescribed antidepressants. It found that combining supplements such as zinc and curcuminoids (the natural compounds in turmeric) with current antidepressants improved symptoms.
“If you’re taking an antidepressant and want it to work better, consider zinc and curcuminoids,” Amen said, adding: “Saffron, zinc, and curcuminoids make a great combination.”
Although cooking with saffron may not provide the levels needed to improve mood, saffron supplements are available as capsules, tablets, and powdered extracts. A daily dose of 30 milligrams is commonly recommended to help reduce symptoms.
However, researchers and experts warn that the long-term use of saffron has not yet been fully studied, and concerns remain regarding its potency as a supplement. According to a medically reviewed article on WebMD, taking saffron in high doses or for long periods “may be unsafe” and could cause anxiety, appetite changes, stomach upset, drowsiness, or headaches.
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